Ivermectin – Anticancer
Well Known Anti-Parasitic
Dr. Nathan Goodyear – A4M Medicine Redefined
If you have cancer (which I do -
https://cancersurvivor.wf4hl.com/
), here is just some of what you need to know about Ivermectin’s Anti-Cancer properties. If you research, just a tiny bit, you will discover a plethora of valuable information that your ‘doctor’ will never disclose and probably is totally UNAWARE. Remember, they make money from the Treatment NOT the Healing! I have listened and written down the key points that Dr. Goodyear said; I could find no article that covered the same points. I did just a bit of searching and found, what appear to be, relevant research articles to support the point given. Also, please read my previously published article: https://skipstein.substack.com/p/ivermectin-cancer
1. Inhibits WNT Beta Catenin Pathways.
Wnt/β-catenin signaling, a highly conserved pathway through evolution, regulates key cellular functions including proliferation, differentiation, migration, genetic stability, apoptosis, and stem cell renewal. The Wnt pathway mediates biological processes by a canonical or noncanonical pathway, depending on the involvement of β-catenin in signal transduction.
2. Ivermectin Induces Apoptosis.
Bladder carcinoma is one of the most common malignancies worldwide, and >90% of all bladder cancers are classified as urothelial carcinomas (UC). Ivermectin, an avermectin derivative, has been reported to be effective against various parasites, and its pharmacokinetic and pharmacodynamic properties as well as safety are well understood in humans. Recently, ivermectin was shown to exhibit therapeutic benefits against various virus infections in vitro, and anticancer activity against various human cancer cells. This study aimed to investigate the anticancer effects of ivermectin in human UC cells. Ivermectin inhibited growth, regulated the cell cycle, and induced apoptosis in human UC cells. It also induced the activation of both extrinsic and intrinsic caspase-dependent apoptotic pathways. Further investigation revealed that ivermectin induced apoptosis in UC cells is mediated via c-Jun N-terminal kinase signaling. Herein, we demonstrated that ivermectin can be used as a new therapeutic agent for treating UC cells. https://www.medsci.org/v19p1567.pdf
3. Ivermectin Induces Autophagy – a kind of Spring Cleaning – great in early stages of some cancers.
Ivermectin induces nonprotective autophagy by downregulating PAK1 and apoptosis in lung adenocarcinoma cells.
https://pubmed.ncbi.nlm.nih.gov/37741955/
4. Ivermectin Inhibits PAK-1 and AKT/MTOR Pro-Growth Signaling Pathways
Ivermectin has powerful antitumor effects, including the inhibition of proliferation, metastasis, and angiogenic activity, in a variety of cancer cells. This may be related to the regulation of multiple signaling pathways by ivermectin through PAK1 kinase. On the other hand, ivermectin promotes programmed cancer cell death, including apoptosis, autophagy and pyroptosis. Ivermectin induces apoptosis and autophagy is mutually regulated. Interestingly, ivermectin can also inhibit tumor stem cells and reverse multidrug resistance and exerts the optimal effect when used in combination with other chemotherapy drugs. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7505114/
5. Ivermectin is Anti-Angiogenic – Removing Waste Nutrients
Ivermectin causes cell death in cancer cell lines by inducing PAK1-mediated cytostatic autophagy, caspase-dependent apoptosis and immunogenic cell death (ICD) through the modulation of some pathways, including the WNT-T cell factor (TCF), Hippo and Akt/mTOR pathways. Ivermectin can affect the growth and proliferation of cancer cells and plays several different roles, such as its functions as an RNA helicase, a small-molecule mimetic of the surface-induced dissociation (SID) peptide, an activator of chloride channel receptors, and an inducer of mitochondrial dysfunction and oxidative stress. In addition, ivermectin induces the multidrug resistance protein (MDR), has potent anti-mitotic activity, targets angiogenesis and inhibits cancer stem-like cells (CSCs). Many studies have proven that ivermectin exerts antitumor effects and might thus benefit patients with cancer
6. Ivermectin Disrupts the Tumor Micro Environment
One proposed mechanism for IVM’s anticancer activity is its ability to disrupt multiple signaling pathways that regulate cell growth and survival. For example, IVM has been shown to inhibit the Akt/mTOR pathway, which is frequently activated in cancer cells and promotes cell growth and proliferation.
https://jlar.rovedar.com/index.php/JLAR/article/download/11/21/44
7. Ivermectin Inhibits Cancer Cell DNA Repair – assists in the chemotherapy attack on cancer cells and cell growth IFF you choose to try that more traditional approach. Ivermectin inhibits the growth of glioma cells by inducing cell cycle arrest and apoptosis in vitro and in vivo https://pubmed.ncbi.nlm.nih.gov/30596403/
References Video: https://www.facebook.com/reel/1031098395400510